Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.K120delFs

c.360delC

Surrounding Variants

8 papers

NM_000546.6

p.S121A

c.361T>G

9 papers

NM_000546.6

p.S121P

c.361T>C

8 papers

NM_000546.6

p.S121T

c.361T>A

1 paper

NM_000546.6

p.K120del1

c.358_359delCTT

1 paper

NM_000546.6

p.A119_K120delFs

c.356_360del5

1 paper

NM_000546.6

p.T118_K120delFs

c.353_360del8

1 paper

NM_000546.6

p.G117_K120del4

c.349_359del12

1 paper

NM_000546.6

p.G112_K120delFs

c.335_360del26

1 paper

NM_000546.6

p.S121fs

c.361_362fs

17 papers

NM_000546.6

p.K120N

c.360G>T

15 papers

NM_000546.6

p.K120fs

c.358_359fs

1 paper

NM_000546.6

p.K120insFs

c.359dupA