Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

105 papers

NM_000546.6

p.K120R

c.359A>G

Surrounding Variants

32 papers

NM_000546.6

p.K120M

c.359A>T

8 papers

NM_000546.6

p.K120T

c.359A>C

1 paper

NM_000546.6

p.Y107_K120delFs

c.319_358del40

17 papers

NM_000546.6

p.K120N

c.360G>T

15 papers

NM_000546.6

p.K120fs

c.358_359fs

1 paper

NM_000546.6

p.K120insFs

c.359dupA

18 papers

NM_000546.6

p.K120N

c.360G>C

33 papers

NM_000546.6

p.K120K

c.360G>A

1 paper

NM_000546.6

p.K120delFs

c.359delT

1 paper

NM_000546.6

p.K120Fs

c.359_360delinsCFs

9 papers

NM_000546.6

p.K120fs

c.358_359fs

25 papers

NM_000546.6

p.K120*

c.358A>T