Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

77 papers

NM_000546.6

p.K120E

c.358A>G

Surrounding Variants

9 papers

NM_000546.6

p.K120fs

c.358_359fs

25 papers

NM_000546.6

p.K120*

c.358A>T

20 papers

NM_000546.6

p.K120Q

c.358A>C

1 paper

NM_000546.6

p.A119_K120insFs

c.357_358insC

1 paper

NM_000546.6

p.K120insFs

c.358_359ins4

5 papers

NM_000546.6

p.A119delFs

c.357delG

1 paper

NM_000546.6

p.S116_A119delFs

c.348_357del10

1 paper

NM_000546.6

p.A119A

c.357C>G

1 paper

NM_000546.6

p.H115_A119insFs

c.344_356dup13

4 papers

NM_000546.6

p.A119fs

c.355_356fs

1 paper

NM_000546.6

p.A119delins

c.356_357delinsTT

1 paper

NM_000546.6

p.A119delins

c.355_356delinsGC