Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G117_A119insFs

c.349_355dup7

Surrounding Variants

18 papers

NM_000546.6

p.A119V

c.356C>T

17 papers

NM_000546.6

p.A119G

c.356C>G

1 paper

NM_000546.6

p.A119insFs

c.356_357insA

11 papers

NM_000546.6

p.A119D

c.356C>A

1 paper

NM_000546.6

p.L114_A119delFs

c.340_355del16

9 papers

NM_000546.6

p.A119S

c.355G>T

1 paper

NM_000546.6

p.T118insFs

c.354dupA

9 papers

NM_000546.6

p.A119P

c.355G>C

13 papers

NM_000546.6

p.A119T

c.355G>A

1 paper

NM_000546.6

p.T118delFs

c.354delT

1 paper

NM_000546.6

p.T118_A119delins

c.354_355delinsCA

1 paper

NM_000546.6

p.S116_T118delFs

c.347_354del8