Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G117_T118delins

c.351_352delinsCT

Surrounding Variants

8 papers

NM_000546.6

p.T118S

c.352A>T

23 papers

NM_000546.6

p.T118A

c.352A>G

5 papers

NM_000546.6

p.T118P

c.352A>C

2 papers

NM_000546.6

p.G117insFs

c.351dupG

13 papers

NM_000546.6

p.G117delFs

c.351delC

1 paper

NM_000546.6

p.L114_T118Fs

c.341_352delinsGFs

2 papers

NM_000546.6

p.G112_G117delFs

c.336_351del16

18 papers

NM_000546.6

p.T118fs

c.352_353fs

19 papers

NM_000546.6

p.G117G

c.351G>T

1 paper

NM_000546.6

p.G117_T118insFs

c.351_352insAT

7 papers

NM_000546.6

p.G117fs

c.349_350fs

5 papers

NM_000546.6

p.G117G

c.351G>C