Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.G117G

c.351G>C

Surrounding Variants

19 papers

NM_000546.6

p.G117G

c.351G>T

1 paper

NM_000546.6

p.G117_T118insFs

c.351_352insAT

7 papers

NM_000546.6

p.G117fs

c.349_350fs

3 papers

NM_000546.6

p.G117G

c.351G>A

1 paper

NM_000546.6

p.S116_G117delFs

c.347_350del4

1 paper

NM_000546.6

p.G108_G117del0

c.324_350del27

1 paper

NM_000546.6

p.S106_G117del0

c.318_350del33

23 papers

NM_000546.6

p.G117V

c.350G>T

21 papers

NM_000546.6

p.G117A

c.350G>C

23 papers

NM_000546.6

p.G117E

c.350G>A

8 papers

NM_000546.6

p.T118S

c.352A>T

23 papers

NM_000546.6

p.T118A

c.352A>G