Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.F113_S116delFs

c.338_348del11

Surrounding Variants

9 papers

NM_000546.6

p.G117W

c.349G>T

1 paper

NM_000546.6

p.G117_T118ins4

c.349_353ins12

1 paper

NM_000546.6

p.G117_T118ins8

c.349_353ins24

15 papers

NM_000546.6

p.G117R

c.349G>C

17 papers

NM_000546.6

p.G117R

c.349G>A

1 paper

NM_000546.6

p.S116delFs

c.348delA

1 paper

NM_000546.6

p.S116del1

c.346_347delAGA

2 papers

NM_000546.6

p.L114_S116delFs

c.341_348del8

1 paper

NM_000546.6

p.L111_S116delFs

c.332_348del17

1 paper

NM_000546.6

p.Y103_S116del14

c.307_347del42

2 papers

NM_000546.6

p.G117fs

c.349_350fs

2 papers

NM_000546.6

p.S116fs

c.346_347fs