Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

48 papers

NM_000546.6

p.F113S

c.338T>C

Surrounding Variants

1 paper

NM_000546.6

p.G112_F113ins0

c.335_337dupGCT

81 papers

NM_000546.6

p.F113C

c.338T>G

12 papers

NM_000546.6

p.F113Y

c.338T>A

1 paper

NM_000546.6

p.F113delins

c.337_338delinsGG

1 paper

NM_000546.6

p.G112_F113del1

c.335_337delAGC

1 paper

NM_000546.6

p.F113ins1

c.337_338insGTC

76 papers

NM_000546.6

p.F113V

c.337T>G

29 papers

NM_000546.6

p.F113L

c.337T>C

19 papers

NM_000546.6

p.F113I

c.337T>A

1 paper

NM_000546.6

p.G112delFs

c.336delG

1 paper

NM_000546.6

p.L111_G112del2

c.331_335del6

1 paper

NM_000546.6

p.R110_G112delFs

c.329_336del8