Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

42 papers

NM_000546.6

p.G112S

c.334G>A

Surrounding Variants

18 papers

NM_000546.6

p.G112C

c.334G>T

18 papers

NM_000546.6

p.G112R

c.334G>C

NM_001126118.2

p.G73R

c.217G>C

2 papers

NM_000546.6

p.L111delFs

c.332_333delCA

1 paper

NM_000546.6

p.G108_L111delFs

c.324_333del10

2 papers

NM_000546.6

p.Y107_L111delFs

c.321_333del13

1 paper

NM_000546.6

p.Y107_L111delFs

c.320_333del14

1 paper

NM_000546.6

p.Y107_L111del5

c.319_332del15

1 paper

NM_000546.6

p.S106_L111del0

c.316_333del18

5 papers

NM_000546.6

p.G112fs

c.334_335fs

12 papers

NM_000546.6

p.G112V

c.335G>T

5 papers

NM_000546.6

p.L111L

c.333G>T

1 paper

NM_000546.6

p.L111ins1

c.332_333insTCT