Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

52 papers

NM_000546.6

p.L111R

c.332T>G

Surrounding Variants

75 papers

NM_000546.6

p.L111P

c.332T>C

68 papers

NM_000546.6

p.L111Q

c.332T>A

1 paper

NM_000546.6

p.L111delFs

c.331delG

7 papers

NM_000546.6

p.R110del1

c.328_329delACG

5 papers

NM_000546.6

p.F109_R110delFs

c.326_329del4

3 papers

NM_000546.6

p.Y107_L111del0

c.320_331del12

5 papers

NM_000546.6

p.L111L

c.333G>T

1 paper

NM_000546.6

p.L111ins1

c.332_333insTCT

14 papers

NM_000546.6

p.L111fs

c.331_332fs

3 papers

NM_000546.6

p.L111L

c.333G>C

5 papers

NM_000546.6

p.L111L

c.333G>A

1 paper

NM_000546.6

p.L111delins

c.332_333delinsCC