Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

182 papers

NM_000546.6

p.R110P

c.329G>C

Surrounding Variants

304 papers

NM_000546.6

p.R110L

c.329G>T

6 papers

NM_000546.6

p.R110insFs

c.328_329insC

2 papers

NM_000546.6

p.F109_R110insFs

c.327_328dupCC

1 paper

NM_000546.6

p.R110insFs

c.329_330ins7

71 papers

NM_000546.6

p.R110H

c.329G>A

1 paper

NM_000546.6

p.R110Fs

c.328_329delinsTFs

27 papers

NM_000546.6

p.R110delFs

c.328delG

2 papers

NM_000546.6

p.F109_R110delFs

c.327_328delGG

2 papers

NM_000546.6

p.F109_R110delFs

c.325_328del4

1 paper

NM_000546.6

p.G108_R110delFs

c.324_328del5

1 paper

NM_000546.6

p.Y107_R110del0

c.320_328del9

13 papers

NM_000546.6

p.G108_R110insFs

c.323_329dup7