Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.F109insFs

c.325_326ins4

Surrounding Variants

25 papers

NM_000546.6

p.R110fs

c.328_329fs

111 papers

NM_000546.6

p.R110C

c.328C>T

NM_001126118.2

p.R71C

c.211C>T

10 papers

NM_000546.6

p.R110G

c.328C>G

1 paper

NM_000546.6

p.F109insFs

c.326_327dupTC

3 papers

NM_000546.6

p.G108_F109insFs

c.324_327dup4

12 papers

NM_000546.6

p.R110S

c.328C>A

1 paper

NM_000546.6

p.F109_R110delins

c.327_328delinsTT

1 paper

NM_000546.6

p.F109_R110delins

c.327_328delinsAT

1 paper

NM_000546.6

p.F109_R110delins

c.325_328delinsATCT

2 papers

NM_000546.6

p.F109del1

c.325_326delGAA

1 paper

NM_000546.6

p.G108_R110Fs

c.324_328delinsAAAFs

1 paper

NM_000546.6

p.G108_R110Fs

c.324_328delinsAAAAFs