Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.F109insFs

c.326_327insG

Surrounding Variants

38 papers

NM_000546.6

p.F109C

c.326T>G

54 papers

NM_000546.6

p.F109S

c.326T>C

9 papers

NM_000546.6

p.F109Y

c.326T>A

2 papers

NM_000546.6

p.F109Fs

c.326delinsCCCAAFs

1 paper

NM_000546.6

p.G108_F109del1

c.323_325delAAC

1 paper

NM_000546.6

p.Y107_F109del0

c.320_325del6

1 paper

NM_000546.6

p.Q104_F109delFs

c.310_325del16

2 papers

NM_000546.6

p.V97_F109delFs

c.291_325del35

1 paper

NM_000546.6

p.Y107_G108insFs

c.320_324dup5

1 paper

NM_000546.6

p.P92_G108insFs

c.276_324dup49

1 paper

NM_000546.6

p.F109insFs

c.325_326insA

49 papers

NM_000546.6

p.F109V

c.325T>G