Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

49 papers

NM_000546.6

p.F109V

c.325T>G

Surrounding Variants

1 paper

NM_000546.6

p.Y107_G108insFs

c.320_324dup5

1 paper

NM_000546.6

p.P92_G108insFs

c.276_324dup49

1 paper

NM_000546.6

p.F109insFs

c.325_326insA

19 papers

NM_000546.6

p.F109L

c.325T>C

12 papers

NM_000546.6

p.F109I

c.325T>A

10 papers

NM_000546.6

p.G108del1

c.322_324delACC

1 paper

NM_000546.6

p.Y107_G108delFs

c.320_324del5

2 papers

NM_000546.6

p.S106_G108del3

c.316_323del9

2 papers

NM_000546.6

p.G105_G108del4

c.313_323del12

1 paper

NM_000546.6

p.Q104_G108del5

c.310_323del15

9 papers

NM_000546.6

p.F109fs

c.325_326fs

1 paper

NM_000546.6

p.G108_F109ins1

c.324_325insAGT