Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G108_F109ins1

c.324_325insAGT

Surrounding Variants

3 papers

NM_000546.6

p.G108insFs

c.322dupG

1 paper

NM_000546.6

p.T102_G108insFs

c.304_323dup20

20 papers

NM_000546.6

p.G108fs

c.322_323fs

1 paper

NM_000546.6

p.G108G

c.324T>A

8 papers

NM_000546.6

p.G108delFs

c.323delC

3 papers

NM_000546.6

p.G108delFs

c.322_323delCC

1 paper

NM_000546.6

p.S106_G108delFs

c.317_323del7

1 paper

NM_000546.6

p.S106_G108delFs

c.316_323del8

1 paper

NM_000546.6

p.G105_Y107del0

c.313_321del9

1 paper

NM_000546.6

p.G105_G108delFs

c.314_323del10

1 paper

NM_000546.6

p.P98_G108delFs

c.293_323del31

1 paper

NM_000546.6

p.Y107_G108insFs

c.320_324dup5