Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.G108A

c.323G>C

Surrounding Variants

7 papers

NM_000546.6

p.G108V

c.323G>T

1 paper

NM_000546.6

p.Y107_G108insFs

c.319_322dup4

1 paper

NM_000546.6

p.G108insFs

c.322_323insGA

1 paper

NM_000546.6

p.G108insFs

c.322_323ins4

21 papers

NM_000546.6

p.G108D

c.323G>A

1 paper

NM_000546.6

p.G108delins

c.322_323delinsAA

2 papers

NM_000546.6

p.Y107_G108del1

c.320_322delCGT

1 paper

NM_000546.6

p.S106_G108delFs

c.316_322del7

1 paper

NM_000546.6

p.G108_F109ins1

c.324_325insAGT

3 papers

NM_000546.6

p.G108insFs

c.322dupG

1 paper

NM_000546.6

p.T102_G108insFs

c.304_323dup20

20 papers

NM_000546.6

p.G108fs

c.322_323fs