Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Y107delFs

c.321delG

Surrounding Variants

13 papers

NM_000546.6

p.G108fs

c.322_323fs

35 papers

NM_000546.6

p.G108C

c.322G>T

1 paper

NM_000546.6

p.G108Fs

c.322delinsCTFs

1 paper

NM_000546.6

p.G108_F109ins5

c.322_326ins15

1 paper

NM_000546.6

p.G108ins1

c.322_323insACA

12 papers

NM_000546.6

p.G108R

c.322G>C

65 papers

NM_000546.6

p.G108S

c.322G>A

1 paper

NM_000546.6

p.Y107delFs

c.320_321delGT

1 paper

NM_000546.6

p.S106_Y107delFs

c.318_321del4

1 paper

NM_000546.6

p.Y103_S106del4

c.307_317del12

7 papers

NM_000546.6

p.G108V

c.323G>T

1 paper

NM_000546.6

p.Y107_G108insFs

c.319_322dup4