Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Y107delFs

c.319_320delTA

Surrounding Variants

4 papers

NM_000546.6

p.Y107Y

c.321C>T

68 papers

NM_000546.6

p.Y107*

c.321C>G

9 papers

NM_000546.6

p.Y107fs

c.319_320fs

6 papers

NM_000546.6

p.Y107insFs

c.320_321insA

1 paper

NM_000546.6

p.Y107insFs

c.319_320dupTA

66 papers

NM_000546.6

p.Y107*

c.321C>A

1 paper

NM_000546.6

p.Y107delFs

c.320delT

1 paper

NM_000546.6

p.Y107delins

c.319_321delinsCAA

1 paper

NM_000546.6

p.S106_Y107delFs

c.316_320del5

1 paper

NM_000546.6

p.Q104_Y107del0

c.312_320del9

1 paper

NM_000546.6

p.Q104_Y107Fs

c.310_321delinsGTFs

13 papers

NM_000546.6

p.G108fs

c.322_323fs