Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.Y107N

c.319T>A

Surrounding Variants

38 papers

NM_000546.6

p.Y107D

c.319T>G

42 papers

NM_000546.6

p.Y107H

c.319T>C

2 papers

NM_000546.6

p.S106delFs

c.318delG

2 papers

NM_000546.6

p.S106delFs

c.317_318delGC

1 paper

NM_000546.6

p.S106del1

c.316_317delGCT

1 paper

NM_000546.6

p.G105_S106del2

c.313_317del6

1 paper

NM_000546.6

p.Q104_S106delFs

c.311_318del8

1 paper

NM_000546.6

p.Q104_S106del0

c.310_318del9

2 papers

NM_000546.6

p.Y103_S106delFs

c.308_318del11

6 papers

NM_000546.6

p.Y107fs

c.319_320fs

4 papers

NM_000546.6

p.S106S

c.318C>T

68 papers

NM_000546.6

p.S106R

c.318C>G