Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S106delFs

c.316delT

Surrounding Variants

13 papers

NM_000546.6

p.S106I

c.317G>T

5 papers

NM_000546.6

p.S106T

c.317G>C

23 papers

NM_000546.6

p.S106N

c.317G>A

1 paper

NM_000546.6

p.S96_S106delFs

c.286_316del31

4 papers

NM_000546.6

p.S106S

c.318C>T

68 papers

NM_000546.6

p.S106R

c.318C>G

1 paper

NM_000546.6

p.S106_Y107insFs

c.318_319insT

3 papers

NM_000546.6

p.S106fs

c.316_317fs

65 papers

NM_000546.6

p.S106R

c.318C>A

2 papers

NM_000546.6

p.S106delFs

c.317delC

14 papers

NM_000546.6

p.S106fs

c.316_317fs

3 papers

NM_000546.6

p.G105_S106delFs

c.313_317del5