Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Y103_G105Fs

c.308_313delinsTFs

Surrounding Variants

95 papers

NM_000546.6

p.G105C

c.313G>T

58 papers

NM_000546.6

p.G105R

c.313G>C

51 papers

NM_000546.6

p.G105S

c.313G>A

1 paper

NM_000546.6

p.Q104delFs

c.311_312delCT

2 papers

NM_000546.6

p.T102_Q104del0

c.304_312del9

1 paper

NM_000546.6

p.Q100_Y103del4

c.298_308del12

1 paper

NM_000546.6

p.P98_Q104del7

c.292_311del21

5 papers

NM_000546.6

p.G105fs

c.313_314fs

68 papers

NM_000546.6

p.G105V

c.314G>T

15 papers

NM_000546.6

p.Q104H

c.312G>T

1 paper

NM_000546.6

p.Q104_G105insFs

c.312_313insTT

1 paper

NM_000546.6

p.Q104_G105ins1

c.312_313insCTC