Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Q104_G105insFs

c.312_313insTT

Surrounding Variants

15 papers

NM_000546.6

p.Q104H

c.312G>T

1 paper

NM_000546.6

p.Q104_G105ins1

c.312_313insCTC

6 papers

NM_000546.6

p.Q104fs

c.310_311fs

2 papers

NM_000546.6

p.Q104insFs

c.311_312insA

15 papers

NM_000546.6

p.Q104H

c.312G>C

3 papers

NM_000546.6

p.Q104Q

c.312G>A

1 paper

NM_000546.6

p.Q104delFs

c.311delT

1 paper

NM_000546.6

p.Q104delins

c.311_312delinsCA

95 papers

NM_000546.6

p.G105C

c.313G>T

58 papers

NM_000546.6

p.G105R

c.313G>C

51 papers

NM_000546.6

p.G105S

c.313G>A

1 paper

NM_000546.6

p.Q104delFs

c.311_312delCT