Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Q100delFs

c.300delC

Surrounding Variants

18 papers

NM_000546.6

p.K101*

c.301A>T

11 papers

NM_000546.6

p.K101E

c.301A>G

11 papers

NM_000546.6

p.K101Q

c.301A>C

1 paper

NM_000546.6

p.K101_T102insCG

c.301_305ins6

1 paper

NM_000546.6

p.V97_Q100del4

c.289_299del12

1 paper

NM_000546.6

p.S95_Q100del6

c.283_299del18

2 papers

NM_000546.6

p.K101fs

c.301_302fs

11 papers

NM_000546.6

p.Q100H

c.300G>T

8 papers

NM_000546.6

p.Q100fs

c.298_299fs

8 papers

NM_000546.6

p.Q100H

c.300G>C

2 papers

NM_000546.6

p.Q100Q

c.300G>A

1 paper

NM_000546.6

p.Q100delFs

c.298_299delTG