Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

89 papers

NM_000546.6

p.Q100*

c.298C>T

NM_001126118.2

p.Q61*

c.181C>T

Surrounding Variants

11 papers

NM_000546.6

p.Q100fs

c.298_299fs

6 papers

NM_000546.6

p.Q100E

c.298C>G

9 papers

NM_000546.6

p.Q100K

c.298C>A

2 papers

NM_000546.6

p.S99_Q100delins

c.297_298delinsTT

16 papers

NM_000546.6

p.P98_S99delFs

c.294_297del4

2 papers

NM_000546.6

p.S96_S99delFs

c.288_297del10

1 paper

NM_000546.6

p.S99S

c.297C>T

11 papers

NM_000546.6

p.S99fs

c.295_296fs

8 papers

NM_001126118.2

p.Q61L

c.182A>T

NM_000546.6

p.Q100L

c.299A>T

7 papers

NM_000546.6

p.Q100R

c.299A>G

7 papers

NM_000546.6

p.Q100P

c.299A>C

1 paper

NM_000546.6

p.Q100insFs

c.298dupC