Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.S99delFs

c.295delA

Surrounding Variants

29 papers

NM_000546.6

p.S99F

c.296C>T

9 papers

NM_000546.6

p.S99C

c.296C>G

1 paper

NM_000546.6

p.S99insFs

c.295_296ins41

10 papers

NM_000546.6

p.S99Y

c.296C>A

1 paper

NM_000546.6

p.S99Fs

c.295_296delinsGFs

1 paper

NM_000546.6

p.S99_Q100ins4

c.295_299ins12

1 paper

NM_000546.6

p.S99insFs

c.295_296insA

6 papers

NM_000546.6

p.S99A

c.295T>G

11 papers

NM_000546.6

p.S99P

c.295T>C

6 papers

NM_000546.6

p.S99T

c.295T>A

1 paper

NM_000546.6

p.S96_P98del0

c.287_292del6

1 paper

NM_000546.6

p.S99S

c.297C>T