Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P98insFs

c.293_294insA

Surrounding Variants

47 papers

NM_000546.6

p.P98L

c.293C>T

12 papers

NM_000546.6

p.P98R

c.293C>G

9 papers

NM_000546.6

p.P98H

c.293C>A

1 paper

NM_000546.6

p.P98delins

c.292_293delinsTT

2 papers

NM_000546.6

p.V97_P98Fs

c.291_293delinsTTFs

1 paper

NM_000546.6

p.L93_P98insFs

c.277_293dup17

15 papers

NM_000546.6

p.P98fs

c.292_293fs

1 paper

NM_000546.6

p.P98P

c.294T>C

10 papers

NM_000546.6

p.V97delFs

c.291delG

1 paper

NM_000546.6

p.V97_P98delFs

c.291_292delGG

11 papers

NM_000546.6

p.P98fs

c.292_293fs

1 paper

NM_000546.6

p.S96_P98delFs

c.287_293del7