Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

46 papers

NM_000546.6

p.P98S

c.292C>T

Surrounding Variants

11 papers

NM_000546.6

p.P98fs

c.292_293fs

12 papers

NM_000546.6

p.P98A

c.292C>G

1 paper

NM_000546.6

p.S94_V97insFs

c.282_291dup10

1 paper

NM_000546.6

p.P98_S99insG

c.292_296ins3

1 paper

NM_000546.6

p.P98_S99ins4

c.292_296ins12

8 papers

NM_000546.6

p.P98T

c.292C>A

1 paper

NM_000546.6

p.V97_P98delins

c.291_292delinsTT

2 papers

NM_000546.6

p.V97delFs

c.290_291delGA

1 paper

NM_000546.6

p.S96_V97delFs

c.288_291del4

1 paper

NM_000546.6

p.S96_V97del2

c.286_290del6

1 paper

NM_000546.6

p.L93_S96delFs

c.277_286del10

47 papers

NM_000546.6

p.P98L

c.293C>T