Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S95_S96insFs

c.285_286insA

Surrounding Variants

6 papers

NM_000546.6

p.S95fs

c.283_284fs

2 papers

NM_000546.6

p.S95S

c.285T>G

2 papers

NM_000546.6

p.S95S

c.285T>C

1 paper

NM_000546.6

p.S95S

c.285T>A

2 papers

NM_000546.6

p.S95delFs

c.284delG

1 paper

NM_000546.6

p.P92_S95del0

c.276_284del9

1 paper

NM_000546.6

p.S96insFs

c.286_287insGT

1 paper

NM_000546.6

p.S96_V97insA

c.286_290ins3

1 paper

NM_000546.6

p.S96_V97insAG

c.286_290ins6

6 papers

NM_000546.6

p.S96A

c.286T>G

11 papers

NM_000546.6

p.S96P

c.286T>C

9 papers

NM_000546.6

p.S96T

c.286T>A