Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_000546.6

p.S95A

c.283T>G

Surrounding Variants

1 paper

NM_000546.6

p.S95ins8

c.283_284ins24

1 paper

NM_000546.6

p.S94insFs

c.282dupA

15 papers

NM_000546.6

p.S95P

c.283T>C

8 papers

NM_000546.6

p.S95T

c.283T>A

5 papers

NM_000546.6

p.S95fs

c.283_284fs

1 paper

NM_000546.6

p.S94delFs

c.282delT

1 paper

NM_000546.6

p.A88_S94del7

c.262_281del21

1 paper

NM_000546.6

p.A86_S94del0

c.258_281del24

23 papers

NM_000546.6

p.S95F

c.284C>T

6 papers

NM_000546.6

p.S95C

c.284C>G

1 paper

NM_000546.6

p.S94_S95insFs

c.282_283dupAT

2 papers

NM_000546.6

p.S95insFs

c.284_285insG