Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S94_S95insFs

c.282_283ins7

Surrounding Variants

1 paper

NM_000546.6

p.S94S

c.282A>T

4 papers

NM_000546.6

p.S94S

c.282A>G

1 paper

NM_000546.6

p.S94_S95insFs

c.282_283insG

1 paper

NM_000546.6

p.S94_S95insFs

c.282_283insCG

1 paper

NM_000546.6

p.S94insFs

c.281_282insC

5 papers

NM_000546.6

p.S94fs

c.280_281fs

2 papers

NM_000546.6

p.S94delFs

c.281delG

1 paper

NM_000546.6

p.L93_S94delFs

c.278_281del4

1 paper

NM_000546.6

p.S95ins8

c.283_284ins24

1 paper

NM_000546.6

p.S94insFs

c.282dupA

7 papers

NM_000546.6

p.S95A

c.283T>G

15 papers

NM_000546.6

p.S95P

c.283T>C