Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.W91_L93delFs

c.273_279del7

Surrounding Variants

1 paper

NM_000546.6

p.S94_S95insTA

c.280_284ins6

8 papers

NM_000546.6

p.S94A

c.280T>G

15 papers

NM_000546.6

p.S94P

c.280T>C

9 papers

NM_000546.6

p.S94T

c.280T>A

3 papers

NM_000546.6

p.L93delFs

c.279delC

1 paper

NM_000546.6

p.P92_L93del2

c.274_278del6

9 papers

NM_000546.6

p.A86_L93delFs

c.257_279del23

6 papers

NM_000546.6

p.S94fs

c.280_281fs

5 papers

NM_000546.6

p.L93L

c.279G>T

1 paper

NM_000546.6

p.L93insFs

c.278dupT

34 papers

NM_000546.6

p.L93fs

c.277_278fs

6 papers

NM_000546.6

p.L93L

c.279G>C