Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L93insFs

c.278dupT

Surrounding Variants

5 papers

NM_000546.6

p.L93L

c.279G>T

34 papers

NM_000546.6

p.L93fs

c.277_278fs

6 papers

NM_000546.6

p.L93L

c.279G>C

9 papers

NM_000546.6

p.L93L

c.279G>A

4 papers

NM_000546.6

p.L93delFs

c.278delA

8 papers

NM_000546.6

p.L93delFs

c.277_278delAG

2 papers

NM_000546.6

p.P92_L93del1

c.276_278delAGG

1 paper

NM_000546.6

p.A86_L93del0

c.258_278del21

2 papers

NM_000546.6

p.P92_L93insFs

c.276_277insC

1 paper

NM_000546.6

p.L93insFs

c.277_278ins10

1 paper

NM_000546.6

p.S94_S95insTA

c.280_284ins6

9 papers

NM_000546.6

p.L93R

c.278T>G