Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

17 papers

NM_000546.6

p.L93M

c.277C>A

Surrounding Variants

24 papers

NM_000546.6

p.L93fs

c.277_278fs

5 papers

NM_000546.6

p.L93L

c.277C>T

32 papers

NM_000546.6

p.L93V

c.277C>G

1 paper

NM_000546.6

p.L93_S94insP

c.277_281ins3

1 paper

NM_000546.6

p.P92_L93Fs

c.276_277delinsGFs

1 paper

NM_000546.6

p.W91_P92delFs

c.273_276del4

2 papers

NM_000546.6

p.P92_L93insFs

c.276_277insC

1 paper

NM_000546.6

p.L93insFs

c.277_278ins10

9 papers

NM_000546.6

p.L93R

c.278T>G

9 papers

NM_000546.6

p.L93P

c.278T>C

6 papers

NM_000546.6

p.L93Q

c.278T>A

14 papers

NM_000546.6

p.L93delFs

c.277delG