Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P92Fs

c.275_276delinsTFs

Surrounding Variants

3 papers

NM_000546.6

p.P92P

c.276C>T

7 papers

NM_000546.6

p.P92fs

c.274_275fs

4 papers

NM_000546.6

p.P92P

c.276C>A

24 papers

NM_000546.6

p.L93fs

c.277_278fs

15 papers

NM_000546.6

p.P92L

c.275C>T

5 papers

NM_000546.6

p.L93L

c.277C>T

1 paper

NM_000546.6

p.P92Fs

c.275delinsTTFs

46 papers

NM_000546.6

p.P92R

c.275C>G

32 papers

NM_000546.6

p.L93V

c.277C>G

1 paper

NM_000546.6

p.P92insFs

c.275_276ins4

1 paper

NM_000546.6

p.L93_S94insP

c.277_281ins3

17 papers

NM_000546.6

p.L93M

c.277C>A