Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P92Fs

c.275delinsTTFs

Surrounding Variants

15 papers

NM_000546.6

p.P92L

c.275C>T

46 papers

NM_000546.6

p.P92R

c.275C>G

1 paper

NM_000546.6

p.P92insFs

c.275_276ins4

13 papers

NM_000546.6

p.P92H

c.275C>A

1 paper

NM_000546.6

p.W91_P92delFs

c.273_274delGC

1 paper

NM_000546.6

p.A86_P92delFs

c.258_274del17

14 papers

NM_000546.6

p.P92S

c.274C>T

3 papers

NM_000546.6

p.P92P

c.276C>T

10 papers

NM_000546.6

p.P92A

c.274C>G

1 paper

NM_000546.6

p.W91insFs

c.273dupG

7 papers

NM_000546.6

p.P92fs

c.274_275fs

1 paper

NM_000546.6

p.P92_L93insT

c.274_278ins3