Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.W91insFs

c.273dupG

Surrounding Variants

14 papers

NM_000546.6

p.P92S

c.274C>T

10 papers

NM_000546.6

p.P92A

c.274C>G

1 paper

NM_000546.6

p.P92_L93insT

c.274_278ins3

1 paper

NM_000546.6

p.P92_L93insAA

c.274_278ins6

9 papers

NM_000546.6

p.P92T

c.274C>A

2 papers

NM_000546.6

p.W91delFs

c.273delC

1 paper

NM_000546.6

p.W91del1

c.271_273delCCA

5 papers

NM_000546.6

p.P92fs

c.274_275fs

7 papers

NM_000546.6

p.W91C

c.273G>T

13 papers

NM_000546.6

p.W91fs

c.271_272fs

8 papers

NM_000546.6

p.W91C

c.273G>C

208 papers

NM_000546.6

p.W91*

c.273G>A