Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.W91insFs

c.271_272insTA

Surrounding Variants

7 papers

NM_000546.6

p.W91L

c.272G>T

2 papers

NM_000546.6

p.W91insFs

c.271_272insT

1 paper

NM_000546.6

p.W91insFs

c.272_273ins4

5 papers

NM_000546.6

p.W91S

c.272G>C

190 papers

NM_000546.6

p.W91*

c.272G>A

2 papers

NM_000546.6

p.W91delFs

c.271delA

1 paper

NM_000546.6

p.W91Fs

c.271_272delinsAFs

2 papers

NM_000546.6

p.S90insFs

c.270dupC

1 paper

NM_000546.6

p.W91_P92ins10

c.271_275ins30

5 papers

NM_000546.6

p.W91G

c.271T>G

10 papers

NM_000546.6

p.W91R

c.271T>C

11 papers

NM_000546.6

p.W91R

c.271T>A