Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.W91G

c.271T>G

Surrounding Variants

2 papers

NM_000546.6

p.S90insFs

c.270dupC

1 paper

NM_000546.6

p.W91_P92ins10

c.271_275ins30

10 papers

NM_000546.6

p.W91R

c.271T>C

11 papers

NM_000546.6

p.W91R

c.271T>A

9 papers

NM_000546.6

p.S90delFs

c.270delG

3 papers

NM_000546.6

p.P89_S90delFs

c.266_269del4

2 papers

NM_000546.6

p.P89_S90delFs

c.266_270del5

1 paper

NM_000546.6

p.A88_S90delFs

c.264_270del7

4 papers

NM_000546.6

p.P87_S90delFs

c.261_270del10

1 paper

NM_000546.6

p.P87_S90delFs

c.260_270del11

1 paper

NM_000546.6

p.A84_S90del0

c.250_270del21

1 paper

NM_000546.6

p.A79_S90del12

c.235_269del36