Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

45 papers

NM_000546.6

p.S90fs

c.268_269fs

Surrounding Variants

1 paper

NM_000546.6

p.S90insFs

c.268_269insG

6 papers

NM_000546.6

p.A88insFs

c.263_264insC

1 paper

NM_000546.6

p.P89insFs

c.266_267dupCC

1 paper

NM_000546.6

p.S90_W91insA

c.268_272ins3

7 papers

NM_000546.6

p.S90A

c.268T>G

9 papers

NM_000546.6

p.S90P

c.268T>C

8 papers

NM_000546.6

p.S90T

c.268T>A

58 papers

NM_000546.6

p.P89delFs

c.267delG

1 paper

NM_000546.6

p.P89_S90Fs

c.267_268delinsGGGFs

7 papers

NM_000546.6

p.A88_P89delFs

c.264_265delGG

2 papers

NM_000546.6

p.A88_P89del1

c.263_265delGGG

1 paper

NM_000546.6

p.A88_P89del2

c.262_266del6