Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P85insFs

c.255dupT

Surrounding Variants

8 papers

NM_000546.6

p.A86S

c.256G>T

1 paper

NM_000546.6

p.A86_P87insA

c.256_260ins3

7 papers

NM_000546.6

p.A86P

c.256G>C

24 papers

NM_000546.6

p.A86T

c.256G>A

1 paper

NM_000546.6

p.P85delFs

c.255delA

1 paper

NM_000546.6

p.P85delFs

c.254_255delAG

1 paper

NM_000546.6

p.A84_P85delFs

c.252_255del4

1 paper

NM_000546.6

p.A84_P85delFs

c.251_255del5

1 paper

NM_000546.6

p.P82_P85del4

c.244_254del12

1 paper

NM_000546.6

p.P80_P85del0

c.240_254del15

1 paper

NM_000546.6

p.P80_P85del6

c.238_254del18

20 papers

NM_000546.6

p.A86fs

c.256_257fs