Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P85insFs

c.254_255insCA

Surrounding Variants

1 paper

NM_000546.6

p.P85_A86insFs

c.255_256ins4

4 papers

NM_000546.6

p.P85_A86insFs

c.255_256insC

2 papers

NM_000546.6

p.P85insFs

c.253_254dupCC

18 papers

NM_000546.6

p.P85fs

c.253_254fs

1 paper

NM_000546.6

p.P85_A86insFs

c.255_256insCA

3 papers

NM_000546.6

p.P85P

c.255T>C

5 papers

NM_000546.6

p.P85P

c.255T>A

19 papers

NM_000546.6

p.P85delFs

c.254delG

2 papers

NM_000546.6

p.A84delFs

c.251_252delGG

1 paper

NM_000546.6

p.A84_P85del1

c.252_254delGGG

8 papers

NM_000546.6

p.A86S

c.256G>T

1 paper

NM_000546.6

p.P85insFs

c.255dupT