Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

14 papers

NM_000546.6

p.P85L

c.254C>T

Surrounding Variants

7 papers

NM_000546.6

p.P85R

c.254C>G

1 paper

NM_000546.6

p.P85insFs

c.254_255insT

1 paper

NM_000546.6

p.P85insFs

c.254_255insA

7 papers

NM_000546.6

p.P85H

c.254C>A

1 paper

NM_000546.6

p.A83_P85delFs

c.247_253del7

1 paper

NM_000546.6

p.P80_P85delFs

c.240_253del14

1 paper

NM_000546.6

p.P85_A86insFs

c.255_256ins4

4 papers

NM_000546.6

p.P85_A86insFs

c.255_256insC

2 papers

NM_000546.6

p.P85insFs

c.253_254dupCC

1 paper

NM_000546.6

p.P85insFs

c.254_255insCA

18 papers

NM_000546.6

p.P85fs

c.253_254fs

1 paper

NM_000546.6

p.P85_A86insFs

c.255_256insCA