Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.A83_A84del2

c.247_251del6

Surrounding Variants

12 papers

NM_000546.6

p.P85fs

c.253_254fs

14 papers

NM_000546.6

p.P85S

c.253C>T

6 papers

NM_000546.6

p.P85A

c.253C>G

1 paper

NM_000546.6

p.P85_A86insC

c.253_257ins3

8 papers

NM_000546.6

p.P85T

c.253C>A

1 paper

NM_000546.6

p.P77_A84delFs

c.231_252del22

14 papers

NM_000546.6

p.P85L

c.254C>T

3 papers

NM_000546.6

p.A84A

c.252C>T

7 papers

NM_000546.6

p.P85R

c.254C>G

1 paper

NM_000546.6

p.A84A

c.252C>G

1 paper

NM_000546.6

p.P85insFs

c.254_255insT

10 papers

NM_000546.6

p.A84fs

c.250_251fs