Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.P82_A83del1

c.246_248delGCC

Surrounding Variants

3 papers

NM_000546.6

p.A84A

c.252C>T

1 paper

NM_000546.6

p.A84A

c.252C>G

10 papers

NM_000546.6

p.A84fs

c.250_251fs

1 paper

NM_000546.6

p.A78_A84del0

c.233_250del18

12 papers

NM_000546.6

p.P85fs

c.253_254fs

18 papers

NM_000546.6

p.A84V

c.251C>T

14 papers

NM_000546.6

p.P85S

c.253C>T

10 papers

NM_000546.6

p.A84G

c.251C>G

6 papers

NM_000546.6

p.P85A

c.253C>G

1 paper

NM_000546.6

p.P85_A86insC

c.253_257ins3

9 papers

NM_000546.6

p.A84D

c.251C>A

8 papers

NM_000546.6

p.P85T

c.253C>A