Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.A84D

c.251C>A

Surrounding Variants

18 papers

NM_000546.6

p.A84V

c.251C>T

10 papers

NM_000546.6

p.A84G

c.251C>G

12 papers

NM_000546.6

p.A84delFs

c.250delC

1 paper

NM_000546.6

p.A83_A84delFs

c.247_250del4

11 papers

NM_000546.6

p.A84S

c.250G>T

6 papers

NM_000546.6

p.A84P

c.250G>C

36 papers

NM_000546.6

p.A84T

c.250G>A

6 papers

NM_000546.6

p.A83delFs

c.248_249delCG

4 papers

NM_000546.6

p.P82_A83del2

c.244_248del6

3 papers

NM_000546.6

p.A84A

c.252C>T

1 paper

NM_000546.6

p.A84A

c.252C>G

10 papers

NM_000546.6

p.A84fs

c.250_251fs