Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.A84P

c.250G>C

Surrounding Variants

11 papers

NM_000546.6

p.A84S

c.250G>T

36 papers

NM_000546.6

p.A84T

c.250G>A

6 papers

NM_000546.6

p.A83delFs

c.248_249delCG

4 papers

NM_000546.6

p.P82_A83del2

c.244_248del6

9 papers

NM_000546.6

p.A84fs

c.250_251fs

5 papers

NM_000546.6

p.A83A

c.249G>T

7 papers

NM_000546.6

p.A83fs

c.247_248fs

4 papers

NM_000546.6

p.A83A

c.249G>A

2 papers

NM_000546.6

p.A83delFs

c.248delG

1 paper

NM_000546.6

p.P82_A83delFs

c.245_248del4

1 paper

NM_000546.6

p.P80_A83delFs

c.238_248del11

18 papers

NM_000546.6

p.A84V

c.251C>T