Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

31 papers

NM_000546.6

p.A83V

c.248C>T

Surrounding Variants

8 papers

NM_000546.6

p.A83G

c.248C>G

1 paper

NM_000546.6

p.A83insFs

c.247dupG

14 papers

NM_000546.6

p.A83E

c.248C>A

3 papers

NM_000546.6

p.A83delFs

c.247delC

4 papers

NM_000546.6

p.P82_A83delFs

c.246_247delCC

1 paper

NM_000546.6

p.A76_A83delFs

c.228_247del20

8 papers

NM_000546.6

p.A83S

c.247G>T

5 papers

NM_000546.6

p.A83A

c.249G>T

7 papers

NM_000546.6

p.A83fs

c.247_248fs

10 papers

NM_000546.6

p.A83P

c.247G>C

13 papers

NM_000546.6

p.A83T

c.247G>A

4 papers

NM_000546.6

p.A83A

c.249G>A