Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_000546.6

p.A83T

c.247G>A

Surrounding Variants

8 papers

NM_000546.6

p.A83S

c.247G>T

10 papers

NM_000546.6

p.A83P

c.247G>C

2 papers

NM_000546.6

p.P82del1

c.244_245delCGG

1 paper

NM_000546.6

p.P80_P82del3

c.238_245del9

1 paper

NM_000546.6

p.A79_A83Fs

c.237_247delinsCGACFs

1 paper

NM_000546.6

p.P75_P82del8

c.223_245del24

1 paper

NM_000546.6

p.P72_P82delFs

c.215_246del32

10 papers

NM_000546.6

p.A83fs

c.247_248fs

2 papers

NM_000546.6

p.P82insFs

c.244dupC

12 papers

NM_000546.6

p.P82fs

c.244_245fs

9 papers

NM_000546.6

p.P82P

c.246G>A

12 papers

NM_000546.6

p.P82delFs

c.245delG