Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.P82delFs

c.245delG

Surrounding Variants

2 papers

NM_000546.6

p.P82insFs

c.244dupC

12 papers

NM_000546.6

p.P82fs

c.244_245fs

9 papers

NM_000546.6

p.P82P

c.246G>A

1 paper

NM_000546.6

p.T81_P82delFs

c.241_245del5

1 paper

NM_000546.6

p.P80_P82delFs

c.239_245del7

1 paper

NM_000546.6

p.P71_T81del11

c.211_242del33

8 papers

NM_000546.6

p.A83S

c.247G>T

10 papers

NM_000546.6

p.A83P

c.247G>C

13 papers

NM_000546.6

p.A83T

c.247G>A

2 papers

NM_000546.6

p.P82del1

c.244_245delCGG

1 paper

NM_000546.6

p.P80_P82del3

c.238_245del9

1 paper

NM_000546.6

p.A79_A83Fs

c.237_247delinsCGACFs