Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.P82Q

c.245C>A

Surrounding Variants

49 papers

NM_000546.6

p.P82L

c.245C>T

8 papers

NM_000546.6

p.P82R

c.245C>G

1 paper

NM_000546.6

p.P82insFs

c.245_246insT

1 paper

NM_000546.6

p.P82insFs

c.245_246insTG

1 paper

NM_000546.6

p.P82delins

c.244_245delinsAT

1 paper

NM_000546.6

p.T81_P82delFs

c.243_244delGT

1 paper

NM_000546.6

p.A79_T81delFs

c.236_243del8

2 papers

NM_000546.6

p.P82insFs

c.244dupC

12 papers

NM_000546.6

p.P82fs

c.244_245fs

9 papers

NM_000546.6

p.P82P

c.246G>A

12 papers

NM_000546.6

p.P82delFs

c.245delG

9 papers

NM_000546.6

p.P82fs

c.244_245fs